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An imidazole derivative with a broad spectrum of antimycotic activityIt inhibits biosynthesis of the sterol ergostolan important component of fungal cell membranesIts action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membranePubChem]
This medication comes in a topical solutiona topical creamand a lozenge formHow often this medication is used will changedepending on the indication for use.
Concomitant use of condomsdiaphragmsor tamponsnot recommendedConfirm diagnosis by KOH smear and/or culturesIf ineffectivereconfirm diagnosis before repeating therapyPregnancyCat.B
Sickle cell anemiasickle cell diseasea blood disease which shortens life expectancyis cause by an inherited abnormal.
Clotrimazole inhibits the movement of calcium and potassium ions across the cell membraneThis action may be responsible for in vitro and animal data demonstrating an antitumor effect of clotrimazoleThis action may also explain why clotrimazole prevents the dehydration of the red blood cell in patients with sickle cell diseaseClotrimazole inhibits the loss of intracellular potassium by blocking the ion transport pathway known as the Gardos channel.
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