When taken under fed conditions, a 20 lower dose of diclofenac in zorvolex capsules resulted in a 23 lower mean systemic exposure aucinf and a 48 lower mean cmax compared to diclofenac potassium ir tablets.
Information about Diclofenac.
Use these medicines with caution in patients with risks factors for cardiovascular diseaseundertaking individual assessment of each patient to ensure the benefits outweigh the risks.
Therapeutic Good’s AdministrationTGAPharmaceutical Benefits SchemePBSGuildLink DrugBank.
In summarywhile use of NSAIDs at prescription-only dosages was already known to increase the risk of high blood pressureheart failureheart attack and strokethe TGA NSAIDs review found that these risks also applied to OTC forms of diclofenacnaproxen and ibuprofen.
Consumers and health professionals are advised that the TGA has completed a review of the cardiovascular risks associated with the use of the non-steroidal anti-inflammatory drugsNSAIDsdiclofenacnaproxenibuprofencelecoxibetoricoxibindomethacinmeloxicam and piroxicam.
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