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Cyclophosphamidealthough effective alone in susceptible malignanciesis more frequently used concurrently or sequentially with other antineoplastic drugs.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administrationwhenever solution and container permitDo not use cyclophosphamide vials if there are signs of meltingMelted cyclophosphamide is a clear or yellowish viscous liquid usually found as a connected phase or in droplets in the affected vials.
Nausea and vomiting commonly occur with cyclophosphamide therapyAnorexia andless frequentlyabdominal discomfort or pain and diarrhea may occurThere are isolated reports of hemorrhagic colitisoral mucosal ulceration and jaundice occurring during therapyThese adverse drug effects generally remit when cyclophosphamide treatment is stopped.
Cyclophosphamide is indicated for the treatment of biopsy proven minimal change nephrotic syndrome in pediatrics patients who failed to adequately respond to or are unable to tolerate adrenocorticosteroid therapy.
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