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Published observational studies suggest that PPI therapy like NEXIUM may be associated with an increased risk of Clostridium difficile associated diarrheaespecially in hospitalized patientsThis diagnosis should be considered for diarrhea that does not improvesee ADVERSE REACTIONS

Acute interstitial nephritis has been observed in patients taking PPIs including NEXIUMAcute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to an idiopathic hypersensitivity reactionDiscontinue NEXIUM if acute interstitial nephritis developssee CONTRAINDICATIONS

NEXIUM is supplied as delayed-release capsules for oral administration or in packets for preparation of delayed-release oral suspensionsThe recommended dosages are outlined in Table 1NEXIUM should be taken at least one hour before meals.

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