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LASSBio-772a 1,3-benzodioxole N-phenylpiperazine derivative a novel potent and selective alpha 1 A1 D adrenoceptorARantagonist selected after screening of functionalized N-phenylpiperazine derivatives in phenylephrine-induced vasoconstriction of rabbit aorta ringsThe affinity of LASSBio-772 for alpha 1 A and alpha 1 B AR subtypes was determined through displacement of3 H]prazosin bindingThis compound presents pharmacological features higher affinity for the alpha 1 A1 D than alpha 1 BARbeing therefore putatively useful for the treatment of the LUTSincluding the BPH in mammals71]
Heating can be relatively low energye.gmicrowavelaser or electrical methodswhen the effects are thought to be due to aadrenoceptor blockade or damage and the net effect akin to ablockers.
In the case of TURPshort-termmainly perioperativecomplications include deathbleedingclot retentiontransurethral resectionTURsyndromehypernatremia resulting in mental confusionnauseavomitingand raised blood pressureurinary tract infectionand inability to voidamong whichbleeding is the most commonSome of these complicationse.gbleeding and TUR syndromemay be serious and life-threateningShort-term complications of TURP include deathbleedingclot retentionTURurinary tract infectionand inability to voidLong-term complications of TURP include failure to voidretrograde ejaculationimpotencepartial or complete incontinenceand retreatment27]
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