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Carmustineetoposideand cisplatin do not affect the pharmacokinetics of ondansetron.
The most common adverse reactions reported in adults in trial(sof prevention of postoperative nausea and vomiting are shown in Table 4In these trial(spatients were receiving multiple concomitant perioperative and postoperative medications in both treatment groups.
Table 2Pediatric Recommended Dosage Regimen for Prevention of Nausea and Vomiting.
Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Previous versions of the ondansetron labels included a warning about QT interval prolongationThe FDA added a new warning to avoid the use of ondansetron in patients with congenital long QT syndrome because these patients are at particular risk for developing Torsade.
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