Reglan metoclopramide is a medicine that increases the movements or contractions of the stomach and intestines.
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Hemodialysis removes relatively little metoclopramideprobably because of the small amount of the drug in blood relative to tissuesSimilarlycontinuous ambulatory peritoneal dialysis does not remove significant amounts of drugIt is unlikely that dosage would need to be adjusted to compensate for losses through dialysisDialysis is not likely to be an effective method of drug removal in overdose situations.
Because metoclopramide produces a transient increase in plasma aldosteronecertain patientsespecially those with cirrhosis or congestive heart failuremay be at risk of developing fluid retention and volume overloadIf these side effects occur at any time during metoclopramide therapythe drug should be discontinued.
A few cases of rashurticariaor bronchospasmespecially in patients with a history of asthmaRarelyangioneurotic edemaincluding glossal or laryngeal edema.
The initial two doses should be 2 mg/kg if highly emetogenic drugs such as cisplatin or dacarbazine are used alone or in combinationFor less emetogenic regimens1 mg/kg per dose may be adequate.
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reglan is a powerful antiemetic manufactured by baxter pharmaceutical.
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