Barbiturates moderate olanzapine is metabolized by the cyp1a2 hepatic microsomal isoenzyme, and inducers of this enzyme such as barbiturates, may increase olanzapine clearance.

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Not approved for dementia-related psychosisbecause of increased risk of cardiovascular or infection-related mortality.

DATA COLLECTION AND ANALYSISData were independently extractedFor homogeneous dichotomous data the random effects relative riskRRthe 95confidence intervalsCIandwhere appropriatethe number needed to treatNNTwere calculated on an intention-to-treat basisFor continuous data the reviewers calculated weighted mean differences.

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