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The elimination half-life of domperidone is prolonged in severe renal impairmentFor repeated administrationthe dosing frequency of Motilium should be reduced to once or twice daily depending on the severity of the impairmentThe dose may also need to be reduced.
Separate in vivo pharmacokinetic/pharmacodynamic interaction studies with oral ketoconazole or oral erythromycin in healthy subjects confirmed a marked inhibition of domperidone’s CYP3A4 mediated first pass metabolism by these drugs.
Therapeutic Good’s AdministrationTGAPharmaceutical Benefits SchemePBSGuildLink DrugBank.
Some medicines are not suitable for people with certain conditionsand sometimes a medicine may only be used if extra care is takenFor these reasonsbefore you start taking domperidone it is important that your doctor knows:
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