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Metronidazole has shown mutagenic activity in in vitro assay systems including the Ames testStudies in mammals in vivo have failed to demonstrate a potential for genetic damage.
Anaerobic InfectionsTreatment of infections in which anaerobic bacteria have been identified or are suspected as pathogensparticularly Bacteroides fragilis and other species of bacteroidesand other species such as fusobacteriaeubacteriaclostridia and anaerobic streptococciFlagyl has been used successfully in septicaemiabacteraemiabrain abscessnecrotising pneumoniaosteomyelitispuerperal sepsispelvic abscesspelvic cellulitispostoperative wound infectionsNoteMetronidazole is inactive against aerobic and facultative anaerobic bacteriaOther IndicationsOral treatment of urogenital trichomoniasis in the femaletrichomonal vaginitisand in the maleand for the treatment of bacterial vaginosisThe male consort of females suffering from urogenital trichomoniasis should be treated concurrentlyall forms of amoebiasisintestinal and extraintestinal disease and that of symptomless cyst passersgiardiasisacute ulcerative gingivitis.
The most serious adverse reactions reported in patients treated with metronidazole have been convulsive seizuresencephalopathyaseptic meningitisoptic and peripheral neuropathythe latter characterized mainly by numbness or paresthesia of an extremitySince persistent peripheral neuropathy has been reported in some patients receiving prolonged administration of metronidazolepatients should be specifically warned about these reactions and should be told to stop the drug and report immediately to their physicians if any neurologic symptoms occurIn additionpatients have reported headachesyncopedizzinessvertigoincoordinationataxiaconfusiondysarthriairritabilitydepressionweaknessand insomniasee WARNINGS
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flagyl 250-mg tablets are round, blue, film coated, with searle and 1831 debossed on one side and flagyl and 250 on the other side; supplied as bottles of 50 and 100.
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