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RECOMMENDATIONHealthcare professionals should be aware that prompt recognition and early treatment is important for improving HLH outcomes and decreasing mortalityDiagnosis is often complicated because early signs and symptoms such as fever and rash are not specificHLH may also be confused with other serious immune-related adverse reactions such as Drug Reaction with Eosinophilia and Systemic SymptomsDRESS
Do not crushchewor break the regular or the extended-release tabletSwallow it whole.
Stopping LAMICTAL suddenly can cause serious problemsSuicidal thoughts or actions can be caused by things other than medicinesIf you have suicidal thoughts or actionsyour healthcare provider may check for other causes.
Although benign rashes are also caused by LAMICTALit is not possible to predict reliably which rashes will prove to be serious or life threateningAccordinglyLAMICTAL should ordinarily be discontinued at the first sign of rashunless the rash is clearly not drug relatedDiscontinuation of treatment may not prevent a rash from becoming life threatening or permanently disabling or disfiguringsee WARNINGS AND PRECAUTIONS
Report any new or worsening symptoms to your doctorsuch asmood or behavior changesdepressionanxietyor if you feel agitatedhostilerestlesshyperactivementally or physicallyor have thoughts about suicide or hurting yourself.
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