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AripiprazoleAbilifylamotrigineLamictallithiumolanzapineZyprexarisperidoneRisperdalConstaand quetiapineSeroquelor ziprasidoneGeodoneither one in combination with lithium or valproateare the only drugs that have been approved by the FDA specifically for maintenance therapy for bipolar disorderThese medications can differ in their ability to prevent manic versus depressive episodesas well as in their side effectsHowevermany other drugs used to treat manic episodes are also used for maintenance treatment.
Inactive ingredientsblackcurrant flavorcalcium carbonatelow-substituted hydroxypropylcellulosemagnesium aluminum silicatemagnesium stearatepovidonesaccharin sodiumand sodium starch glycolate.
Some estrogen-containing oral contraceptives have been shown to decrease serum concentrations of lamotriginesee CLINICAL PHARMACOLOGYDosage adjustments will be necessary in most patients who start or stop estrogen-containing oral contraceptives while taking LAMICTALsee DOSAGE AND ADMINISTRATIONDuring the week of inactive hormone preparationpill-free weekof oral contraceptive therapyplasma lamotrigine levels are expected to riseas much as doubling at the end of the weekAdverse reactions consistent with elevated levels of lamotriginesuch as dizzinessataxiaand diplopiacould occur.
The overall adverse reaction profile for LAMICTAL was similar between females and malesbetween elderly and nonelderly patientsand among racial groups.
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