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Cdifficile produces toxins A and Bwhich contribute to the development of CDADHypertoxin-producing strains of Cdifficile cause increased morbidity and mortalityas these infections can be refractory to antimicrobial therapy and may require colectomyCDAD must be considered in all patients who present with diarrhea following antibiotic useCareful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.
Advise patients that allergic reactionsincluding serious allergic reactionscould occur and that serious reactions require immediate treatmentAsk the patient about any previous hypersensitivity reactions to KEFLEXother beta-lactamsincluding cephalosporinsor other allergens Advise patients that diarrhea is a common problem caused by antibacterial drugs and usually resolves when the drug is discontinuedSometimesfrequent watery or bloody diarrhea may occur and may be a sign of a more serious intestinal infectionIf severe watery or bloody diarrhea developsadvise patients to contact their healthcare providerCounsel patients that antibacterial drugs including KEFLEXshould only be used to treat bacterial infectionsThey do not treat viral infectionse.gthe common coldWhen KEFLEX is prescribed to treat a bacterial infectiontell patients that although it is common to feel better early in the course of therapythe medication should be taken exactly as directedSkipping doses or not completing the full course of therapy may1decrease the effectiveness of the immediate treatment and2increase the likelihood that bacteria will develop resistance and will not be treatable by KEFLEX or other antibacterial drugs in the future.
The safety and effectiveness of Keflex in pediatric patients was established in clinical trials for the dosages described in the dosage and administration sectionsee Dosage and Administration2.2
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