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The effect of proton pump inhibitorsPPIon the systemic exposure to the clopidogrel active metabolite following multiple doses of Plavix 75 mg evaluated in dedicated drug interaction studies is presented in Figure 1.
XDo not use in pregnancyRisks involved outweigh potential benefitsSafer alternatives exist.
Avoid concomitant use of Plavix with omeprazole or esomeprazoleIn clinical studiesomeprazole was shown to reduce significantly the antiplatelet activity of Plavix when given concomitantly or 12 hours apartA similar reduction in antiplatelet activity was observed with esomeprazole when given concomitantly with PlavixDexlansoprazolelansoprazole and pantoprazole had less effect on the antiplatelet activity of Plavix than did omeprazole or esomeprazolesee WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY
Do not stop taking Plavix without talking to the doctor who prescribes it for youPeople who stop taking Plavix too soon have a higher risk of having a heart attack or dyingIf you must stop Plavix because of bleedingyour risk of a heart attack may be higher.
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