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Information about Colchicine.
Colchicine is a substrate for both CYP3A4 and the transport protein P-gpIn the presence of CYP3A4 or P-gp inhibitorsthe concentrations of colchicine in the blood increaseToxicityincluding fatal caseshave been reported during concurrent use of CYP3A4 or P-gp inhibitors such as macrolidesclarithromycin and erythromycinciclosporinketoconazoleitraconazolevoriconazoleHIV protease inhibitorscalcium channel blockersverapamil and diltiazemand disulfiramsee section 4.4
Colchicine can prevent attacks of gout and control FMF only as long as you take the medicationContinue to take colchicine even if you feel wellDo not stop taking colchicine without talking to your doctor.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
General information about the safe and effective use of colchicine capsules.
Avoid eating grapefruit or drinking grapefruit juice while taking colchicine capsulesIt can increase your chances of getting serious side effects.
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adjust colchicine dosage see dosage under dosage and administration 152 154.
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