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Patients on prolonged clomiPHENE citrate therapy may show elevated serum levels of desmosterolThis is most likely due to a direct interference with cholesterol synthesisHoweverthe serum sterols in patients receiving the recommended dose of clomiPHENE citrate are not significantly alteredOvarian cancer has been infrequently reported in patients who have received fertility drugsInfertility is a primary risk factor for ovarian cancerhoweverepidemiology data suggest that prolonged use of clomiPHENE may increase the risk of a borderline or invasive ovarian tumor.
5Uterine FibroidsCaution should be exercised when using clomiPHENE citrate in patients with uterine fibroids due to the potential for further enlargement of the fibroids.
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