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Sarcina si lactatie Anumite studii pe animale au aratat ca glucocorticoizii administrati la mama in doze mari pot determina malformatii fetaleStudii reproductive umane adecvate nu au fost efectuate cu corticoiziDe aceea folosirea corticosteroizilor in sarcinalactatie sau la femei cu potential fertil se recomanda in cazul in care beneficiile terapiei depasesc evident riscul potential pentru mamaembrion sau fatDeoarece evidenta sigurantei in sarcina este inconsistentamedicamentul va fi folosit in sarcina numai in cazuri de absoluta necesitateCorticosteroizii traverseaza placentaNou-nascutii mamelor care au primit doze substantiale de corticoizi in timpul sarcinii trebuie atent monitorizati si evaluati pentru o posibila insuficienta adrenalianaNu se cunosc efectele corticoizilor asupra travaliului si a expulsiei fetaleCorticoizii trec in laptele matern.

Applies to methylprednisolonecompounding powderinjectable powder for injectioninjectable suspensionoral tablet.

Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystociafetal deathretained placentaand metritis.

MEDROL Tablets like prednisoloneare contraindicated in animals with arrested tuberculosispeptic ulceracute psychosesand Cushingoid syndromeThe presence of diabetesosteoporosischronic psychotic reactionspredisposition to thrombophlebitishypertensioncongestive heart failurerenal insufficiencyand active tuberculosis necessitates carefully controlled useSome of the above conditions occur only rarely in dogs and cats but should be kept in mind.

MEDROL is indicated in dogs and cats with conditions known to be responsive to anti-inflammatory corticosteroidsincluding collagendermalallergicocularotic and musculoskeletalas well as various chronic or recurrent diseasesulcerative colitis and nephrosis

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