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Monitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conductione.gdigitaliscalcium channel blockers and beta-blockersSinus bradycardia resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concomitantly with diltiazem or verapamil.
In several studies with oral clonidine hydrochloridea dose-dependent increase in the incidence and severity of spontaneous retinal degeneration was seen in albino rats treated for six months or longerTissue distribution studies in dogs and monkeys showed a concentration of clonidine in the choroid.
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the participants were divided and placed into one of four groups standalone clonidine, standalone methylphenidate, clonidine plus methylphenidate, or a placebo.
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