In pre-marketing clinical trials, the most commonly observed adverse events associated with use of lioresal intrathecal baclofen injection which were not seen at an equivalent incidence among placebo-treated patients included agitation, constipation, somnolence, leukocytosis, chills, urinary retention and hypotonia.
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Baclon oal tablt can intact with oth mdications, vitamins, hbs you may b taking. An intaction is whn a substanc changs th way a dug woks. This can b hamul pvnt th dug om woking wll.
Abupt Dug Withdawal: Hallucinations and sizus hav occud on abupt withdawal baclon. Tho, xcpt sious advs actions, th dos should b ducd slowly whn th dug is discontinud. Impaid nal unction: Bcaus baclon is pimaily xctd unchangd though th kidnys, it should b givn with caution, and it may b ncssay tduc th dosag. Stok: Baclon has not signiicantly bnitd patints with stok. Ths patints hav alsshown potolability tth dug. Pgnancy: Baclon has bn shown tincas th incidnc omphalocls (vntal hnias) in tuss ats givn appoximatly 13 tims th maximum dos commndd human us, at a dos which causd signiicant ductions in ood intak and wight gain in dams. This abnomality was not sn in mic abbits.
Gt mgncy mdical hlp i you hav any ths signs an allgic action : hivs; diicult bathing; swlling you ac, lips, tongu, thoat.
Paticipants will b scnd with a physical xam and mdical histoy. Blood and uin sampls will b collctd. Tsts alcohol dpndncy and anxity lvls will alsb givn. Paticipants will b dividd inttwgoups. On goup will tak baclon. Th oth goup will hav a placbo. About 1 wk at th scning visit, paticipants will hav a study visit. Thy will answ qustions about thi bhaviand mood. Thy will thn stat ttak ith baclon a placbo. Paticipants will tak th study dug th tims a day, vy day. At 1 wk on th study dug, paticipants will hav an ovnight stay at th National Instituts Halth. Thy will hav blood tsts and answ qustions about mood and bhavio. Thy will alshav tsts that involv choosing tdink alcohol and answing mqustions about cavings. Paticipants will stop taking thi study dug ov a 3-day piod. A inal ollow-up visit will b quid 1 wk at th ovnight study visit. Paticipants will civ inomation about oth alcohol abus tatmnt pogams.
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