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HOW TO USETake this medication by mouth with or without food as directed by your doctorusually once daily.If you are using the suspension form of this medicationshake the bottle well before each doseCarefully measure the dose using a special measuring device/spoonDo not use a household spoon because you may not get the correct dose.The dosage is based on your medical condition and response to treatmentFor childrenthe dosage is also based on weight.Use this medication regularly in order to get the most benefit from itTo help you remembertake it at the same time each dayIt is important to continue taking this medication even if you feel wellMost people with high blood pressure do not feel sick.For the treatment of high blood pressureit may take 2 to 4 weeks before you get the full benefit of this medicationFor the treatment of heart failureit may take weeks to months before you get the full benefit of this medicationTell your doctor if your condition does not improve or if it worsenssuch as your blood pressure readings remain high or increase
Angiotensin converting enzymeACEis a peptidyl dipeptidase which catalyzes the conversion of angiotensin I to the pressor substanceangiotensin IIInhibition of ACE results in decreased plasma angiotensin IIwhich leads to increased plasma renin activitydue to removal of negative feedback of renin releaseand decreased aldosterone secretionAlthough the latter decrease is smallit results in a small increase in serum KIn patients treated with lisinopril and a thiazide diuretic there was essentially no change in serum potassiumsee Precautions
ACE is identical to kininase IIThuslisinopril may also block the degradation of bradykinina potent vasodilator peptideHoweverthe role that this plays in the therapeutic effects of lisinopril is unknown.
If you have diabetesdo not use Prinivil together with any medication that contains aliskirensuch as Tekturna or Tekamlo
Surgery/AnesthesiaIn patients undergoing major surgery or during anesthesia with agents that produce hypotensionlisinopril blocks angiotensin II formationsecondary to compensatory renin releaseIf hypotension occurs and is considered to be due to this mechanismit can be corrected by volume expansion.
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