, seizure, injunction, other judicial proceeding against all firms, including compounding pharmacies, attempting to manufacture, ship, or deliver colchicine injection because of potentially serious health risks associated with use of the injection.
Information about Colchicine.
Colchicine is potentially toxic so it is important not to exceed the dose prescribed by a physician with the necessary knowledge and experience.
The first stage of acute colchicine toxicity typically begins within 24 hours of ingestion and includes gastrointestinal symptoms such as abdominal painnauseavomitingdiarrheaand significant fluid lossleading to volume depletionPeripheral leukocytosis may also be seenLife-threatening complications occur during the second stagewhich occurs 24 to 72 hours after drug administrationattributed to multi-organ failure and its associated consequencesDeath usually results from respiratory depression and cardiovascular collapseIf the patient survivesrecovery of multi-organ injury may be accompanied by rebound leukocytosis and alopecia starting about 1 week after the initial ingestionTreatment of colchicine overdose should begin with gastric lavage and measures to prevent shockOtherwisetreatment is symptomatic and supportiveNo specific antidote is knownColchicine is not effectively removed by hemodialysisSee Pharmacokinetics
Colchicine is used to treat the symptoms of gout or familial Mediterranean feverFamilial Mediterranean fever is passed down in familiesIt can cause inflammationpain and swellingin the jointslungsor abdomenstomach area
About all of your medical conditions if you have kidney or liver problems if you are pregnant or plan to become pregnantIt is not known if colchicine capsules can harm your unborn babyTalk to your healthcare provider if you are pregnant or plan to become pregnantif you are breastfeeding or plan to breastfeedColchicine can pass into your breast milk and may harm your babyTalk to your healthcare provider about the best way to feed your baby if you take colchicine capsules.
Colchicine is contraindicated in patients with renal or hepatic impairment who are taking a P-gp inhibitore.gciclosporinverapamil or quinidineor a strong CYP3A4 inhibitore.gritonaviratazanavirindinavirclarithromycintelithromycinitraconazole or ketaconazolesee section 4.3
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the known 2- and 3-demethylcolchicines dmcs underwent o -sulfate conjugation in addition to the previously described o -glucuronidation.
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