It is recommended that the premarin dose should be accompanied by a glass of water, and preferably be taken on a full stomach to reduce stomach upset.
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Abnormal uterine bleeding or spottingdysmenorrhea or pelvic painincrease in size of uterine leiomyomatavaginitisincluding vaginal candidiasischange in cervical secretioncystitis-like syndromeapplication site reactions of vulvovaginal discomfortincluding burningirritationand genital pruritusendometrial hyperplasiaendometrial cancerprecocious pubertyleukorrhea.
13There is an increase in the risk of gallbladder disease in women receiving HRTsee Conditions that need supervision
A woman without a uterus does not need a progestinIn some caseshoweverhysterectomized women with a history of endometriosis may need a progestinsee WARNINGS AND PRECAUTIONS
In women with pre-existing hypertriglyceridemiaestrogen therapy may be associated with elevations of plasma triglycerides leading to pancreatitisConsider discontinuation of treatment if pancreatitis occurs.
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