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In larger dosesfludrocortisone acetate inhibits endogenous adrenal cortical secretionthymic activityand pituitary corticotropin excretionpromotes the deposition of liver glycogenandunless protein intake is adequateinduces negative nitrogen balance.
Adequate studies have not been performed in animals to determine whether fludrocortisone acetate has carcinogenic or mutagenic activity or whether it affects fertility in males or females.
Corticosteroids should be used with caution in patients with nonspecific ulcerative colitis if there is a probability of impending perforationabscessor other pyogenic infectionCorticosteroids should also be used cautiously in patients with diverticulitisfresh intestinal anastomosesactive or latent peptic ulcerrenal insufficiencyhypertensionosteoporosisand myasthenia gravis.
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