In proactive, 5238 patients with type 2 diabetes and a prior history of macrovascular disease were treated with actos n 2605 , force-titrated up to 45 mg daily or placebo n 2633 in addition to standard of care.
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Sthoat, muscl pain, wight gain, tooth poblms may occu. I any ths cts psist wosn, notiy you doctphamacist pomptly.
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It is impotant tinstuct patints tadh tditay instuctions and thav blood glucos and glycosylatd hmoglobin tstd gulaly. Duing piods stss such as v, tauma, inction, sugy, mdication quimnts may chang and patints should b mindd tsk mdical advic pomptly. Patints whxpinc an unusually apid incas in wight dma whdvlop shotnss bath oth symptoms hat ailu whil on ACTOS should immdiatly pot ths symptoms ta physician. Tll patints tpomptly stop taking ACTOS and sk immdiat mdical advic i th is unxplaind nausa, vomiting, abdominal pain, atigu, anoxia, dak uin as ths symptoms may b du thpatotoxicity. Tll patints tpomptly pot any sign macoscopichmatuia oth symptoms such as dysuia uinay ugncy that dvlop incas duing tatmnt as ths may b du tbladd canc. Tll patints ttak ACTOS onc daily. ACTOS can b takn with without mals. I a dos is missd on on day, th dos should not b doubld th ollowing day. Whn using combination thapy with insulin oth antidiabtic mdications, th isks hypoglycmia, its symptoms and tatmnt, and conditions that pdispos tits dvlopmnt should b xplaind tpatints and thi amily mmbs. Inom mal patints that tatmnt with ACTOS, lik oth thiazolidindions, may sult in an unintndd pgnancy in som pmnopausal anovulatoy mals du tits ct on ovulation [s Us In Spciic Populations ].
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