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There are several readily identifiable causes of reduced theophylline clearanceIf the total daily dose is not appropriately reduced in the presence of these risk factorssevere and potentially fatal theophylline toxicity can occurCareful consideration must be given to the benefits and risks of theophylline use and the need for more intensive monitoring of serum theophylline concentrations in patients with the following risk factors:
Institute supportive careincluding establishment of intravenous accessmaintenance of the airwayand electrocardiographic monitoring.
Using this medicine with any of the following medicines is not recommendedYour doctor may decide not to treat you with this medication or change some of the other medicines you take.
Take this medication by mouth as directed by your doctorusually once or twice dailySince different manufacturers have different ways to take this medicationask your doctor or pharmacist about the best time(sto take your brand of theophylline and if you should take the drug with or without food.
Overview Theophylline is rapidly and completely absorbed after oral administration in solution or immediate-release solid oral dosage formTheophylline does not undergo any appreciable pre-systemic eliminationdistributes freely into fat-free tissues and is extensively metabolized in the liver.
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