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Long-term animal studies to determine the carcinogenic potential of tretinoin have not been performedStudies in hairless albino mice suggest that tretinoin may accelerate the tumorigenic potential of weakly carcinogenic light from a solar simulatorIn other studieswhen lightly pigmented hairless mice treated with tretinoin were exposed to carcinogenic doses of UVB lightthe incidence and rate of development of skin tumors was reducedDue to significantly different experimental conditionsno strict comparison of these disparate data is possibleAlthough the significance of these studies to man is not clearpatients should avoid or minimize exposure to sun.
There may be some discomfort or peeling during the early days of treatmentSome patients also notice that their skin begins to take on a blush.
Applying an excessive amount of Retin-A gel may result inpillingof the medicationIf this occursuse a thinner layer of gel with the next application.
If you have recently used products containing sulfurresorcinol or salicylic aciduse tretinoin with cautionWait until the effects of such products on the skin have decreased before using tretinoin.
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