Renagel should not be taken by and is dangerous for patients with low phosphorus levels and those who have a bowel obstruction.
Information about Renagel.
The safety of sevelamer hydrochloride has not been established in breast-feeding womenRenagel should only be given to breast-feeding women if clearly needed and after a careful risk/benefit analysis has been conducted for both the mother and the infantsee section 5.3
Patients with chronic renal failure are predisposed to developing metabolic acidosisWorsening of acidosis has been reported upon switching from other phosphate binders to sevelamer in a number of studies where lower bicarbonate levels in the sevelamer-treated patients compared to patients treated with calcium-based binders were observedCloser monitoring of serum bicarbonate levels is therefore recommended.
PregnancyNot absorbed systemically following oral administration and maternal use not expected to result in fetal exposure to the drug.
Patients with renal insufficiency may develop hypocalcaemia or hypercalcaemiaRenagel does not contain calciumSerum calcium levels should be monitored as is done in normal follow-up of a dialysis patientElemental calcium should be given as a supplement in case of hypocalcaemia.
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