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Supravalvular aortic stenosis has been produced in foetuses by near-fatal oral doses of vitamin D in pregnant rabbitsThere is no evidence to suggest that vitamin D is teratogenic in humans even at very high dosesRocaltrol should be used during pregnancy only if the benefits outweigh the potential risk to the foetus.
Treatment of Hypercalcemia and Overdosage in Dialysis Patients and Hypoparathyroidism Patients.
In patients with normal renal functionchronic hypercalcemia may be associated with an increase in serum creatinineWhile this is usually reversibleit is important in such patients to pay careful attention to those factors which may lead to hypercalcemiaRocaltrolcalcitrioltherapy should always be started at the lowest possible dose and should not be increased without careful monitoring of the serum calciumAn estimate of daily dietary calcium intake should be made and the intake adjusted when indicated.
The effectiveness of treatment depends in part on an adequate daily intake of calciumwhich should be augmented by dietary changes or supplements if necessaryThe capsules should be swallowed with a little water.
Oral Rocaltrolcalcitriolmay normalize plasma ionized calcium in some uremic patientsyet fail to suppress parathyroid hyperfunctionIn these individuals with autonomous parathyroid hyperfunctionoral Rocaltrolcalcitriolmay be useful to maintain normocalcemiabut has not been shown to be adequate treatment for hyperparathyroidism.
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the recommended initial dose of rocaltrol is 0.
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