Florinef tablets should be stored at 2 c to 8 c in a refrigerator.
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The use of Florinef AcetateFludrocortisone Acetate Tablets USPin patients with active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimenIf corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivityclose observation is necessary since reactivation of the disease may occurDuring prolonged corticosteroid therapy these patients should receive chemoprophylaxis.
Corticosteroids should be used with caution in patients with nonspecific ulcerative colitis if there is a probability of impending perforationabscessor other pyogenic infectionCorticosteroids should also be used cautiously in patients with diverticulitisfresh intestinal anastomosesactive or latent peptic ulcerrenal insufficiencyhypertensionosteoporosisand myasthenia gravis.
Prolonged use of corticosteroids may produce posterior subcapsular cataractsglaucoma with possible damage to the optic nervesand may enhance the establishment of secondary ocular infections due to fungi or viruses.
Patients should be monitored regularly for blood pressure determinations and serum electrolyte determinationssee WARNINGS
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patients randomized to treatment with the combination tablet of niacin florinef tablets and lovastatin initially received 500 mg20 mg expressed as mg of niacinmg of lovastatin once daily before bedtime.
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