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Chickenpox and measles can have a more serious or even fatal course in pediatric and adult patients on corticosteroidsIn pediatric and adult patients who have not had these diseasesparticular care should be taken to avoid exposureThe contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not knownIf exposed to chickenpoxprophylaxis with varicella zoster immune globulinVZIGmay be indicatedIf exposed to measlesprophylaxis with immune globulinIGmay be indicatedSee the respective package inserts for VZIG and IG for complete prescribing informationIf chickenpox developstreatment with antiviral agents may be considered.
An acute myopathy has been observed with the use of high doses of corticosteroidsmost often occurring in patients with disorders of neuromuscular transmissione.gmyasthenia gravisor in patients receiving concomitant therapy with neuromuscular blocking drugse.gpancuroniumThis acute myopathy is generalizedmay involve ocular and respiratory musclesand may result in quadriparesisElevation of creatinine kinase may occurClinical improvement or recovery after stopping corticosteroids may require weeks to years.
Are there any special precautions patients should be aware of before starting treatment?
IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT.
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