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In a study of healthy volunteerschloroquine significantly reduced the bioavailability of ampicillinAn interval of at least two hours between intake of this agent and chloroquine should be observed.

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absorption rapid and almost completely distribution widely distributed into body tissues protein binding 55 metabolism partially hepatic to main metabolite, desethylchloroquine excretion urine 50 as unchanged drug ; acidification of urine increases elimination.

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