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Oal Anti-coagulants: Th concomitant administation ATOLIP CV with oal anti-coagulants is not commndd sinc it may incas th intnsity blding. Atovastatin had nclinically signiicant ct on pothombin tim whn administd tpatints civing chonic waain tatmnt. Although th administation clopidogl 75 mg p day did not modiy th phamacokintics S-waain (a CYP2C9 substat) Intnational Nomalizd ati(IN) in patints civing long-tm waain thapy, at high concntations in vit, clopidogl inhibits CYP2C9. Co-administation ATOLIP CV with waain incass th isk blding bcaus indpndnt cts clopidogl on hmostasis.
Patints should b placd on an appopiat lipid-lowing dit bciving ATOLIP CV , and should continu this dit duing tatmnt. Th commndd dosag is on capsul onc daily.
Th isk myopathy duing tatmnt with dugs in this class is incasd with concunt administation cyclospoin, ibic acid divativs, ythomycin, claithomycin, th hpatitis C potas inhibittlapvi, combinations HIV potas inhibitos, including saquinavi plus itonavi, lopinavi plus itonavi, tipanavi plus itonavi, daunavi plus itonavi, osampnavi, and osampnavi plus itonavi, niacin, azol antiungals. Physicians considing combind thapy with ATOLIP CV and ibic acid divativs, ythomycin, claithomycin, a combination itonavi plus saquinavi, lopinavi plus itonavi, daunavi plus itonavi, osampnavi, osampnavi plus itonavi, azol antiungals, lipid-modiying doss niacin should caully wigh th potntial bnits and isks and should caully monitpatints any signs symptoms muscl pain, tndnss, waknss, paticulaly duing th initial months thapy and duing any piods upwad dosag titation ith dug. Low stating and maintnanc doss ATOLIP CV should b considd whn takn concomitantly with th aomntiond dugs. Piodic CPK dtminations may b considd in such situations, but th is nassuanc that such monitoing will pvnt th occunc sv myopathy.
Gmibozil: Du tan incasd isk myopathy/habdomyolysis whn HMG-CoA ductas inhibitos a co-administd with gmibozil, concomitant administation ATOLIP CV with gmibozil should b avoidd.
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