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Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
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Budesonide is a substrate for CYP3A4Avoid use with CYP3A4 inhibitorsConcomitant oral administration of a strong CYP3A4 inhibitorketoconazolecaused an eight-fold increase of the systemic exposure to oral budesonideInhibitors of CYP3A4e.gketoconazoleitraconazoleritonavirindinavirsaquinavirerythromycinand cyclosporinecan increase systemic budesonide concentrationssee CLINICAL PHARMACOLOGY
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